Double marker test is given to 35 years above women and those who have type 1 diabetes
and a family history of birth defects.
A double marker test is a blood test and ultrasound which is given to pregnant women. To
find out any chromosomal malformation in the fetus. This test is also conducted because it
plays a major role in finding neurological conditions in the fetus like Edward’s Syndrome
and another kind of down’s syndrome and etc. Chromosomal abnormalities can result in major
problems in post-baby born but it’s extremely rare.
Who should be taking this test
- This test is mainly given to women who are 35 years old.
- Those who have childbirth defects in history.
- Also for those who have diabetes problems in their family history.
Uses of double marker test
- What this test is taken.
- To find out down syndrome.
- to find out Trisomy 18.
- To check whether unborn people will suffer mental disorders.
- Women who have any syndrome in this following.
Is the double marking test performed on an empty stomach?
No that is not necessary. However, if a woman is on certain medications, it should be
avoided before testing.
Disadvantages of double marker test
There are no disadvantages or still, there are no scientifically proven results which proves
disadvantages of this test…
This test is considered in very rare cases so it’s a little difficult to find this test in all cities.
Advantages of double marker test
This test helps in To find out any chromosomal malformation in the fetus. plays a major
role in finding neurological conditions in the fetus like Edward’s Syndrome and another kind
of down’s syndrome.
Cost of double marker test
This may vary from hospital to hospital from city to city. It may cost you from 1000INR to
5000INR ( 13 to 66 USD ). But it’s very important you do research and choice a good and
better laboratory for this test.. because child health is important and the right report is very
important for your pregnancy.
How this test is performed
A double marker test is performed by taking blood samples to look for HCG AND PAPP -A (
HCG =human chorionic gonadotropin)
( PAPP-A = Pregnancy-associated plasma protein A)and with ultrasound. The blood samples
help doctors to determine neurological or Chromosome defects with the baby.
HCG is tested because it produces placenta during pregnancy. The level of the placenta
indicates trisomy 18 and down syndrome.
A low level of PAPP-A indicates a high risk of down syndrome.
What a normal report of HCG AND PAPP-A
HCG level should be 25700 to 28800 Miu/ml for all age women
PAPP- A normal level will be- 1 MOM (multiple of median) for all age women.
What is Down syndrome?
In the medical field, Down syndrome is known as trisomy genetic disorder. Each cell is made
up of 46 chromosomes, of which 23 are chromosomes. To form an embryo two cells with 23
chromosomes each must combine (sperm and egg) to form a 46-pair zygote, which
eventually develops into an embryo. In some cases, during cell division, an extra
chromosome is transferred between two chromosomes. So instead of two, there are three
chromosomes. In Down syndrome, 21 pairs have three chromosomes instead of two. This
anomaly is seen as the most common physical and cognitive features seen with Down
Two-dimensional markers help determine this condition by examining mutant markers if the
embryo with this extra chromosome is present. These marks can also be used to diagnose
other diseases, namely, Edward syndrome (chromosome trisomy 18) and Patau syndrome
(chromosome trisomy 13). Since this is very rare compared to Down syndrome, it is rarely