Double marker test is given to 35 years above women and those who have type 1 diabetes
and a family history of birth defects.
what is a double marker test?
A double marker test is a blood test and ultrasound which is given to pregnant women. To
find out any chromosomal malformation in the fetus. This test is also conducted because it
plays a major role in finding neurological conditions in the fetus like Edward’s Syndrome
and another kind of down’s syndrome and etc. Chromosomal abnormalities can result in major
problems post-baby born but it’s extremely rare.
Who should be taking this test
- This test is mainly given to women who are 35 years old.
- Those who have childbirth defects in history.
- Also for those who have diabetes problems in their family history.
Uses of double marker test
- helps To find out about down syndrome.
- to find out Trisomy 18.
- To check whether unborn people will suffer mental disorders.
- Women who have any syndrome in this following.
Double marker test report analysis
double marker test is performed by blood test and by ultrasound. the normal range of hCG in all pregnant women of all ages should be 25700-288000 mIU/ml. you can analyze your double marker test report by knowing the normal value of hCG. for better knowledge of the dual marker test, it’s always recommended to consult the doctor.
Is the double marking test performed on an empty stomach?
No that is not necessary. However, if a woman is on certain medications, it should be
avoided before testing.
Disadvantages of double marker test
There are no disadvantages or still, there are no scientifically proven results which proves
disadvantages of this test…
This test is considered in very rare cases so it’s a little difficult to find this test in all cities.
Advantages of double marker test
This test helps in To find out any chromosomal malformation in the fetus. plays a major
role in finding neurological conditions in the fetus like Edward’s Syndrome and another kind
of down’s syndrome.
Cost of double marker test
This may vary from hospital to hospital from city to city. It may cost you from 1000INR to
5000INR ( 13 to 66 USD ). But it’s very important you do research and choice a good and
better laboratory for this test.. because child health is important and the right report is very
important for your pregnancy.
How this test is performed
A double marker test is performed by taking blood samples to look for HCG AND PAPP -A (
HCG =human chorionic gonadotropin)
( PAPP-A = Pregnancy-associated plasma protein A)and with ultrasound. The blood samples
help doctors to determine neurological or Chromosome defects with the baby.
HCG is tested because it produces placenta during pregnancy. The level of the placenta
indicates trisomy 18 and down syndrome.
A low level of PAPP-A indicates a high risk of down syndrome.
What a normal report of HCG AND PAPP-A
HCG level should be 25700 to 28800 Miu/ml for all age women
PAPP- A normal level will be- 1 MOM (multiple of median) for all age women.
What is Down syndrome?
In the medical field, Down syndrome is known as trisomy genetic disorder. Each cell is made
up of 46 chromosomes, of which 23 are chromosomes. To form an embryo two cells with 23
chromosomes each must combine (sperm and egg) to form a 46-pair zygote, which
eventually develops into an embryo.
In some cases, during cell division, an extra chromosome is transferred between two chromosomes. So instead of two, there are three chromosomes. In Down syndrome, 21 pairs have three chromosomes instead of two. This
anomaly is seen as the most common physical and cognitive features seen with Down syndrome.
Two-dimensional markers help determine this condition by examining mutant markers if the
embryo with this extra chromosome is present. These marks can also be used to diagnose
other diseases, namely, Edward syndrome (chromosome trisomy 18) and Patau syndrome
(chromosome trisomy 13). Since this is very rare compared to Down syndrome, it is rarely
In which week dual marker test is done?
dual Marker Test can be done within 14 weeks to support the evidence for taking dual
Why dual marker test is done?
A dual marker test is done to check the baby’s mental health and also to detect
chromosomal abnormalities in the fetus. It checks the presence of beta hCG and also PAPP-A.
Is the dual marker test mandatory?
No, a dual marker test is not mandatory for every pregnant woman. It’s only mandatory for
a woman who have a family history of baby born defects and also the woman who have cross 35
Can double marker test identify gender?
Any test which is done after 7 weeks of pregnancy can be easily identified with the baby’s gender.
But it’s illegal in India to know pre-born babies’ gender.
Is a double marker test done on empty stomach?
No, we can take the dualMarker Test any time, there is no specific time like we should be
taken on an empty stomach.
When dual marker test is done?
Double marker is done in Pregnancy, when pregnant women are above 35 years old, or when
pregnant women’s family have history child born defects. Or to check the baby’s mental health.
What if the dual marker test is positive?
If the dual marker test is positive that means your baby may have a high risk to suffer from down
Can the dual marker test be wrong?
The dual marker test is a very reliable test. This test helps in detecting the abnormalities of
baby’s like mental health.
Is a double marker test required?
Yes, a dual marker test is required if a woman is over 35 years. And required if you have a history
of family birth defects. And also required to check the baby’s mental health and etc.
Is the double marker test painful?
It depends on you. For some people taking a blood sample is painful and for some people, it’s
not painful. Dual marker test required your blood test samples to determine hCG and
Double marker test Vs nipt
Nipt ( non-invasive prenatal screening test )is more effective compare to a dual marker test
according to Delhi/May 30, 2018- A nationwide study across 10 hospitals. Both tests are done
with blood test samples.
Double marker test Vs triple marker test?
Both the triple marker test and the dual marker test performed the same job. Where double
marker test only checks the hCG and PAPP-A and in triple marker, test check AFP, HCG, and
estriol in it.
Double marker test Vs quadruple test?
Both double marker tests and the quadruple tests are blood tests. Dual marker test using
conducted to identify the hCG and PAPP-A in the woman blood .and a quadruple test
conducted to identify the disabilities of pre-born babies and to identify down syndrome.
Double marker test Vs nt scan
A dual marker test is performed to determine the hCG and PAPP-A in pregnant women
where nt scan is a screening test which is performed in 3 months from Pregnancy. To measure
the size of common tissue called nuchal translucency.
Double marker test or quadruple test?
It depends on the doctor’s prescriptions. And on the symptoms of Pregnant women.
A dual marker test is performed to identify the hCG and PAPP-A in the blood and where
quadruple is conducted to identify the disabilities of pre-born babies.
Double Marker Test or nt scan
Both play a different role in Pregnancy. Nt scan is screening conducted in 3 months from
Pregnancy to measure the common size of tissues. And dual marker test is conducted to
determine the hCG and PAPP-A.
Double marker test fasting or non-fasting?
Double Marker Test is non- fasting because it can be performed at any time on empty
stomach and also after food.
Double marker test cost Vs nipt cost?
Cost depends on the hospital and the city you get tested. The average cost of double marker
the test varies from 13 to 66 USD dollars. Where nipt may vary from 800 to 3000 dollars.
Double marker test cost Vs triple marker test cost.
Double marker test cost may vary from hospital to hospital, from city to city and it may vary from
$13 to $66. And the triple marker test cost may cost you $23.
Double marker test cost Vs quadruple test cost.
Quadruple test cost may vary from 2000INR to 3000INR. and the double marker test may vary
from 1000INR to 5000INR.
Double marker test cost Vs nt scan cost.
Nt scan cost may vary from city to city, hospital to hospital. It may vary from 1900INR to
2000INR. where the double marker test costs you around 1000INR to 5000INR.
How YouTube can teach you about double marker test?
YouTube is a growing video platform, where you can find amazing content of knowledge
and education. As YouTube a learning flatform it can teach you amazing things about double
marker tests, you will get 100’s of videos on YouTube teaching you about double marker tests.
Just search “double marker test” on YouTube and you will find amazing Content on double
Why does nobody know about the double marker test?
Double marker tests are rare. Because it’s only conducted if Pregnant woman is above 35
years or in case if Pregnant woman haves a history of family deficit births or In Case to check
the mental health of the pre-born baby. It’s also conducted to determine the down syndrome.
Several tests are performed during pregnancy to monitor the health of the mother and
baby. Basically, a marking test is performed to check for birth defects in the developing
fetus. Typically, these tests are performed to monitor the fetus’s Down syndrome, a rare
chromosomal abnormality that affects the baby’s developmental and mental development.
A two-mark test is a blood test done during the first trimester between the 11th and 13th
week of pregnancy.
dual marker test
Dual tests were performed with NT scan (Nuchal translucency scan).
Blood tests measure two symptoms such as PAPP-A (pregnancy-related plasma proteins)
and hCG (human chorionic gonadotrophin), while an NT scan measures subcutaneous fluid
behind the baby’s neck.
The results of both tests are tested to see if the child has Down’s syndrome. In the event that
there is a risk of Down’s syndrome, reports indicate abnormal levels of hCG and PAPP-A and
a high NT scan rate. Depending on the results, a pregnant woman may fall into the category
of ‘screen positive or high risk’ or ‘screen negative or low screen’. A quad mark (quad screen)
the test is a blood test done during pregnancy, during the 15th to 20th week of pregnancy.
Similar to the triple screen, the quad marker screen provides information about the risk of
certain birth defects in a child. In this experiment, four markers in the blood were measured
as Alpha-fetoprotein (AFP) produced by the fetal liver, HCG is the hormone produced by the
placenta, Estriol is the estrogen produced by the placenta and fetal liver, and Inhibin -A is
another hormone produced by the placenta.
Worldwide, the average incidence of Down syndrome is between 1 and 1 in 1,100 live births.
Every year about 3,000 to 5,000 babies are born with this chromosome. In the United States,
an estimated 6,000 babies are born with Down syndrome. According to the World Health
The organization, about 60 to 80% of children with Down syndrome have hearing problems. 40
to 45% accounts for congenital heart disease.
Intestinal paralysis also occurs at higher levels
in children with Down syndrome. Some children with Down syndrome, especially those with
a serious heart condition, often fail to develop in childhood.